Computer simulations of the activity of RND efflux pumps
نویسندگان
چکیده
منابع مشابه
Molecular Dynamics Computer Simulations of Multidrug RND Efflux Pumps
Over-expression of multidrug efflux pumps of the Resistance Nodulation Division (RND) protein super family counts among the main causes for microbial resistance against pharmaceuticals. Understanding the molecular basis of this process is one of the major challenges of modern biomedical research, involving a broad range of experimental and computational techniques. Here we review the current st...
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Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, genes encoding for multidrug efflux pumps belong to the core of bacterial genomes...
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15 صفحه اولRelative Gene Expression of RND-Type Efflux Pumps in Tigecycline Resistant Acinetobacter Baumannii Isolated from Training Hospitals in Tehran, Iran
Background: Appearance of multi-drug resistance (MDR) Acinetobacter baumannii imposes limitation on antibiotic therapy in patients. Detection of MDR A. baumannii can play a crucial role to prevent MDR strains spreading in hospitals. The aim of this study was determination the efflux pumps gene expression in tigecyclin resistance strains in collected isolates from selected training hospitals in ...
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ژورنال
عنوان ژورنال: Research in Microbiology
سال: 2018
ISSN: 0923-2508
DOI: 10.1016/j.resmic.2017.12.001